"bismuth subsalicylate metabolism"

bismuth Clinical Pharmacology Drug Monograph

Bismuth subsalicylate (BSS) is an oral antidiarrheal agent. It is effective for control of nonspecific diarrhea and prophylactic treatment of traveler''s diarrhea. Although bismuth salts were first used in infectious disease (e.g., for treatment of syphilis) in 1889, the beneficial actions of bismuth in treating infectious diarrhea were not ...

Bismuth subsalicylate | C7H6BiO4

Bismuth subsalicylate: Uses, Interactions, Mechanism of ...

Metabolism of bismuth subsalicylate and intracellular ...

Metabolism of bismuth subsalicylate and intracellular accumulation of bismuth by Fusarium sp. strain BI. Dodge AG(1), Wackett LP. Author information: (1)BioTechnology Institute, University of Minnesota, St. Paul, MN 5510, USA.

f C l in cal Journal of Clinical Toxicology

2020-2-6 · bismuth subnitrate (BSN) and bismuth subsalicylate (BSS) in the small intestine of rats is below 1% [22], indicating low bioavailability of bismuth from these pharmaceuticals in mammalian bodies. Relatively large amounts of bismuth, up to 480 mg per day, are therefore given in treating H. pylori infections. Most of the bismuth precipitates in the

Bismuth subgallate | C7H6BiO6

Bismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration when exposed to sunlight. It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet elucidated antimicrobial and hemostatic actions, bismuth subgallate is most ...

Bismuth oxide salicylate

The test substance, bismuth subsalicylate, is a solid under all environmental conditions and is only slightly soluble in water (0.19 to 22.83 mg/L). It has a low vapour pressure (0.000034 Pa at 20°C) therefore any environmental release will result in little release directly to atmosphere. The bismuth component of bismuth subsalicylate cannot ...

(PDF) Metabolism of Bismuth Subsalicylate and ...

Metabolism of Bismuth Subsalicylate and Intracellular Accumulation of Bismuth by Fusarium sp. Strain BI March 2005 Applied and Environmental Microbiology 71(2):876-82

Bismuth subsalicylat

Bismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. . COX-1, COX-2, . Bismuth (III) salicylate basic, Bismuth oxysalicylate, Bismuth ...

The Antimicrobial Effects and Metabolomic Footprinting of ...

2013-10-9 · Currently, organic salts of bismuth (i.e., bismuth subsalicylate, bismuth subcitrate, and bismuth subnitrate) are used as antimicrobial agents in medicine [11–15]. Bismuth preparations are particularly effective in the treatment of different gastrointestinal disorders including gastritis, duodenal ulcers, and traveler''s diarrhea .

HELIDAC Therapy DRAFT

2009-3-31 · Bismuth subsalicylate chewable tablets: Each pink round tablet contains 262.4 mg bismuth subsalicylate (102 mg salicylate) for oral administration. Bismuth subsalicylate is a fine, white, odorless, and tasteless powder that is stable and non-hygroscopic. It is a highly insoluble salt of trivalent bismuth and salicylic acid.

Bismuth subsalicylate: Uses, Interactions, Mechanism of ...

517  · Metabolism. Bismuth subsalicylate undergo hydrolysis at pH levels lesser than three. It is …

Bismuth Subsalicylate

Bismuth subsalicylate (BSS) (Fig. 12 A) is one of the most widely used drugs for the rapid relief of heartburn, stomach upset and diarrhea.The basic core of BSS is Bi 9 O 7 containing a central Bi 6 octahedron with seven of the eight faces capped by an oxo ligand (O 2 −) and three additional Bi(III) ions in these ligands lloidal bismuth citrate (CBS) and ranitidine bismuth citrate (RBC ...

Bismuth

2014-10-17 · Overdosage/Toxicology: Symptoms of toxicity: Subsalicylate: Hyperpnea, nausea, vomiting, tinnitus, hyperpyrexia, metabolic acidoses/respiratory alkalosis, tachycardia, and confusion; seizures in severe overdose, pulmonary or cerebral edema, respiratory failure, cardiovascular collapse, coma, and death. Note: Each 262.4 mg tablet of bismuth subsalicylate contains an equivalent of 130 mg aspirin ...

Bismuth subsalicylate | C7H6BiO4

Bismuth Subsalicylate is a bismuth salt of salicylic acid. Little absorbed from the gastrointestinal tract, bismuth subsalicylate exerts a local effect on the gastric mucosa, coating it and protecting it from the corrosive effects of acid and pepsin. This agent …

The absorption of bismuth and salicylate from oral doses ...

Plasma bismuth and plasma salicylate concentrations were measured before and after three 30-ml oral doses of bismuth salicylate (Pepto-Bismol liquid) in 10 fasting healthy subjects. From 0 to 120 min following the first dose of bismuth salicylate, the plasma bismuth concentration was less than 1 ng/ …

Metabolism of bismuth subsalicylate and intracellular ...

2005-2-1 · Enrichment cultures were conducted using bismuth subsalicylate as the sole source of carbon and activated sludge as the inoculum. A pure culture was obtained and identified as a Fusarium sp. based on spore morphology and partial sequences of 18S rRNA, translation elongation factor 1-α, and β-tubulin genes. The isolate, named Fusarium sp. strain BI, grew to equivalent densities when using ...

MATERIAL SAFETY DATA SHEET OF BISMUTH …

2015-7-14 · MATERIAL SAFETY DATA SHEET OF BISMUTH SUBSALICYLATE SECTION 1. PRODUCT IDENTIFICATION MSDS Name: Bismuth subsalicylate Chemical Formula: C7H5BiO 4 Synonym ... reactions), metabolism (loss of appetite, acidosis), …

Bismuth subsalicylate | C7H6BiO4

Bismuth Subsalicylate is a bismuth salt of salicylic acid. Little absorbed from the gastrointestinal tract, bismuth subsalicylate exerts a local effect on the gastric mucosa, …

Mechanism of gastroprotection by bismuth subsalicylate ...

Furthermore, the protective ability of bismuth subsalicylate (BSS) was assessed at concentrations of 25, 50, and 100 mg/liter. Incubation of GC with ethanol, HCI, and NaOH increased superoxide anion production by approximately 8.0-, 6.1-and 7.1-fold and increased hydroxyl radical production by 13.3-, 9.6-, and 8.9-fold, respectively, compared ...

Bismuth subsalicylate: history, chemistry, and safety

Pepto-Bismol, which contains bismuth subsalicylate (BSS) as the active ingredient, has been marketed in the United States for more than 80 years. In the gastrointestinal tract, BSS is converted to salicylic acid and insoluble bismuth salts. The salicylate portion of BSS is extensively absorbed (grea …

Phenytoin: Uses, Interactions, Mechanism of Action ...

Bismuth subsalicylate: The protein binding of Phenytoin can be decreased when combined with Bismuth subsalicylate. Bisoprolol: The metabolism of Bisoprolol can be increased when combined with Phenytoin. Bleomycin: The serum concentration of Phenytoin can be decreased when it …

Pepto-Bismol 17.5mg/Ml Oral Suspension

The oral bioavailability of bismuth administered as Bismuth subsalicylate is extremely low. Very little is known about bismuth distribution in human tissue. Renal clearance is the primary route of elimination for absorbed bismuth, however biliary clearance may also have a role. The remainder is eliminated as insoluble bismuth salts in the faeces.

Bismuth drugs kill bacteria by disrupting metabolism ...

Bismuth drugs kill bacteria by disrupting metabolism. Researchers have combined several methods to elucidate the key mechanisms of action of a bismuth-based drug on Helicobacter pylori. The results could help researchers design new antibiotics. H. pylori exists in the digestive tract of …

Salicylate toxicity leads to metabolic acidosis and ...

Salicylates are a group of chemicals derived from salicylic acid. E.g. aspirin (acetylsalicylic acid), salicylic acid, bismuth subsalicylate (Pepto-Bismol), Mesalamine (5-aminosalicylic acid), etc. Salicylate overdose causes a high anion gap metabolic acidosis in both children and adults and respiratory alkalosis 2/2 to hyperventilation in adults.

Binding and killing of bacteria by bismuth subsalicylate

Bismuth subsalicylate (BSS) is a compound without significant aqueous solubility that is widely used for the treatment of gastrointestinal disorders. BSS was able to bind bacteria of diverse species, and these bound bacteria were subsequently killed. A 4-log10 reduction of viable bacteria occurred w …

High molecular weight poly(L-lactide) via ROP with …

human metabolism. Hence, organocatalyst cannot be less toxic. Bismuth is the least toxic heavy metal, even slightly less toxic than zinc.16,17 In the United States, bismuth subsalicylate (BiSub) has been an over-the-counter drug for more than 100 years (e.g., under the trade mark "Peptobismol").18 It has been demonstrated (and

COMPARATIVE ABSORPTION OF BISMUTH IN …

1998-12-4 · The absorption of bismuth from De-Nol (bismuth subcitrate, DN), Pepto-Bismol (bismuth subsalicylate, PB) and bismuth sucrose octasulfate (BISOS) was examined in male Sprague–Dawley rats after a single oral dose of each compound (60 mg bismuth).

Metabolism of bismuth subsalicylate and intracellular ...

T1 - Metabolism of bismuth subsalicylate and intracellular accumulation of bismuth by Fusarium sp. strain BI. AU - Dodge, Anthony G. AU - Wackett, Lawrence P. PY - 2005/2. Y1 - 2005/2. N2 - Enrichment cultures were conducted using bismuth subsalicylate as the sole source of …

Pepto-Bismol

David H. Shaw, in Pharmacology and Therapeutics for Dentistry (Seventh Edition), 2017 Bismuth Subsalicylate. Bismuth subsalicylate (Pepto-Bismol) is a commonly used OTC agent in the treatment of various gastrointestinal symptoms and diseases, including dyspepsia and acute diarrhea, and in the prevention of traveler''s diarrhea is the only OTC bismuth compound available in the United States ...

Bismuth Subsalicylate | COX | | ...

Metabolism Proteases Microbiology Others Pfizer ... Bismuth SubsalicylatePepto-Bismol,Pepto-Bismol。,Bismuth Subsalicylate ...